TF105060

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TF105060

Tree families database

Beijing Genomics Institute

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Accession	TF105060
Symbol	BRCA1
Family Name	Breast cancer type 1 susceptibility protein
Synonyms	RNF53; BRCC1; breast cancer 1, early onset; RING finger protein 53
Family Size	seed: 4 / full: 25
Old Accessions	TF336113
Descriptions	Tumor suppressor gene associated with breast and ovarian cancers in human. BRCA1 has been shown to play a role in DNA repair, transcriptionnal response to DNA damage and the G2/M DNA-damage checkpoint. BRCA1 in complex with BARD1 has ubiquitin ligase activity. [PMID: 11832208] BRCA1 may also be involved in topoisomerase IIalpha-dependent DNA decatenation. [PMID: 15965487]
Last Modified	2006-02-01
Comment	Decided against inclusion of worm brc-1 (homolog of BRCA1 in Wormbase) because alignment is only on N-terminus ring finger and C-terminus BRCT domains and there are no other supporting evidence. HMMER searches using only human, mouse, chicken and frog sequences fail to find genes in fly and fish but new assembly of Fugu genome (December 2005) has a likely family member (NEWSINFRUG00000121752). The existence of BRCA1 genes in lower organisms will have to be revisited when more intermediate organisms are available.

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Instructions ATV TreeView

BRCA1_HUMAN
BRCA1_PANTR
BRCA1_F2_MACMU
BRCA1_BOVIN
BRCA1_CANFA
Brca1_F2_MOUSE
Brca1_RAT
NP_001029141_MONDO
NP_989500_F2_CHICK

View Curated Seed Tree
Instructions ATV TreeView

BRCA1_HUMAN
Brca1_MOUSE
Q52P67_MONDO
ENSGALT00000004392_CHICK

View MultiAlignment
Instructions

ENSBTAG00000022520
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:Q864U1] chromosome19: 44479659-44548566 Taxon: Bos taurus [9913]

ENSCAFG00000014600
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:Q95153] chromosome9: 23278874-23342346 Taxon: Canis familiaris [9615]

ENSCPOG00000013609
genescaffoldGeneScaffold_1792: 12173-105612 Taxon: Cavia porcellus [10141]

ENSDNOG00000016069
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_6683: 78246-208842 Taxon: Dasypus novemcinctus [9361]

ENSECAG00000016974
BRCA1 (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q9BDV4] chromosome11: 20052916-20106500 Taxon: Equus caballus [9796]

ENSEEUG00000002709
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_2052: 41282-151479 Taxon: Erinaceus europaeus [9365]

ENSETEG00000002829
BRCA1 (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q9BDT9] genescaffoldGeneScaffold_3476: 72320-256357 Taxon: Echinops telfairi [9371]

ENSFCAG00000013146
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_5167: 400325-474817 Taxon: Felis catus [9685]

ENSGALG00000002781
breast cancer 1, early onset [Source:RefSeq_peptide;Acc:NP_989500] chromosome27: 4789998-4809054 Taxon: Gallus gallus [9031]

ENSLAFG00000014533
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_1747: 29595-134065 Taxon: Loxodonta africana [9785]

ENSMICG00000014262
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_4661: 183732-257307 Taxon: Microcebus murinus [30608]

ENSMLUG00000004135
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_3869: 360436-415123 Taxon: Myotis lucifugus [59463]

ENSMMUG00000001329
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:Q6J6I9] chromosome16: 53179516-53262332 Taxon: Macaca mulatta [9544]

ENSMODG00000015150
NULL chromosome2: 193078138-193151009 Taxon: Monodelphis domestica [13616]

ENSMUSG00000017146
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:P48754] chromosome11: 101351080-101410408 Taxon: Mus musculus [10090]

ENSOCUG00000003883
Breast and ovarian cancer susceptibility 1 (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q20CP8] genescaffoldGeneScaffold_7117: 53381-83173 Taxon: Oryctolagus cuniculus [9986]

ENSOGAG00000003951
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_1220: 190799-273534 Taxon: Otolemur garnettii [30611]

ENSOPRG00000010889
BRCA1 (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q8WMT6] genescaffoldGeneScaffold_1128: 36100-97467 Taxon: Ochotona princeps [9978]

ENSPPYG00000008363
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:Q6J6J0] chromosome17: 46293487-46376247 Taxon: Pongo pygmaeus [9600]

ENSPTRG00000009236
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:Q9GKK8] chromosome17: 14390557-14473399 Taxon: Pan troglodytes [9598]

ENSRNOG00000020701
Breast cancer type 1 susceptibility protein homolog. [Source:Uniprot/SWISSPROT;Acc:O54952] chromosome10: 90513665-90570179 Taxon: Rattus norvegicus [10116]

ENSSARG00000004577
BRCA1 (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q8WMT5] genescaffoldGeneScaffold_1640: 23720-92795 Taxon: Sorex araneus [42254]

ENSSTOG00000000494
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] genescaffoldGeneScaffold_5511: 125809-205365 Taxon: Spermophilus tridecemlineatus [43179]

ENSG00000012048
Breast cancer type 1 susceptibility protein (RING finger protein 53). [Source:Uniprot/SWISSPROT;Acc:P38398] chromosome17: 38451220-38529639 Taxon: Homo sapiens [9606]

ENSTBEG00000012984
genescaffoldGeneScaffold_374: 186441-251327 Taxon: Tupaia belangeri [37347]

Last Modified Thu Aug 2 03:14:18 2007

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