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TF314028
Tree families database The Sanger Institute Beijing Genomics Institute
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Descriptions
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AccessionTF314028
SymbolAIFM3
Family NameApoptosis-inducing factor 1, mitochondrial precursor 3
Family Sizefull: 113

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Instructions ATV TreeView

BGIOSIFCE008461.1_ORYSA
BGIOSIFCE008462.1_ORYSA
At3g27820.1_ARATH
At3g09940.1_ARATH
At5g03630.1_ARATH
At3g52880.1_ARATH
At1g63940.2_ARATH
AIFM1_HUMAN
AIFM1_PANTR
AIFM1_MACMU
AIFM1_BOVIN
AIFM1_CANFA
Aifm1_MOUSE
Pdcd8_RAT
AIFM1_F3_MONDO
NP_001007491_CHICK
pdcd8_XENTR
pdcd8_F3_BRARE
AIFM1_TETNG
AIFM1_F5_GASAC
ENSCINT00000012225_CIOIN
ENSCSAVT00000009867_CIOSA
CG7263-RB_DROME
dper_GLEANR_20844_caf1_DROPE
AAEL002016-RA_AEDAE
XP_317418_ANOGA
Smp_137540_SCHMA
WBGene00006937_F2_CAEEL
CBG13330_CAEBR
cr01.sctg35.wum.37.1_CAERE
BGIOSIFSE038419.1_ORYSA
aif1_SCHPO
AIFM3_HUMAN
AIFM3_PANTR
AIFM3_F2_MACMU
NP_001039746_BOVIN
Aifm3_MOUSE
RGD1306028_RAT
AIFM3_CHICK
AIFM3_XENTR
LOC569177_BRARE
AIFM3_TETNG
AIFM3_GASAC
XP_425400_CHICK
ENSDART00000088098_BRARE
ENSTNIT00000021358_TETNG
ENSGACT00000011233_GASAC
ENSTNIT00000019446_TETNG
ENSGACT00000027134_GASAC
ENSCINT00000015763_CIOIN
ENSCSAVT00000014140_CIOSA
ENSCSAVT00000000102_CIOSA
CG4199-RF_DROME
CG10700-RA_DROME
AAEL011158-RA_AEDAE
Q6VFG0_ANOGA
WBGene00017640_CAEEL
CBG11327_CAEBR
cr01.sctg1.wum.880.1_CAERE

View MultiAlignment
Instructions

AAEL002016
disulfide oxidoreductase
supercontigsupercont1.47: 2703454-2713384
Taxon: Aedes aegypti [7159]
AAEL011158
disulfide oxidoreductase
supercontigsupercont1.544: 582238-598651
Taxon: Aedes aegypti [7159]
AGAP003904
Ferredoxin reductase (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q6VFG0]
chromosome2R: 45773171-45773864
Taxon: Anopheles gambiae [7165]
AGAP008044
chromosome3R: 4806167-4808803
Taxon: Anopheles gambiae [7165]
At1g63940
68414.m07240 monodehydroascorbate reductase, putative similar to monodehydroascorbate reductase GB:AAD28178 [Brassica juncea]
chromosome1: 23733868-23737197
Taxon: Arabidopsis thaliana [3702]
At3g09940
68416.m01190 monodehydroascorbate reductase, putative similar to monodehydroascorbate reductase (NADH) GB:JU0182 (Cucumis sativus)
chromosome3: 3056505-3059108
Taxon: Arabidopsis thaliana [3702]
At3g27820
68416.m03470 monodehydroascorbate reductase, putative similar to cytosolic monodehydroascorbate reductase GB:BAA77214 [Oryza sativa]
chromosome3: 10316485-10319118
Taxon: Arabidopsis thaliana [3702]
At3g52880
68416.m05827 monodehydroascorbate reductase, putative monodehydroascorbate reductase (NADH), Lycoperison esculentum, PIR:T06407
chromosome3: 19612454-19615344
Taxon: Arabidopsis thaliana [3702]
At5g03630
68418.m00322 monodehydroascorbate reductase, putative monodehydroascorbate reductase (NADH), cucumber, PIR:JU0182
chromosome5: 922376-924615
Taxon: Arabidopsis thaliana [3702]
Bm1_41010A
Bmal_supercontig14973: 133364-138459
Taxon: Brugia malayi [6279]
CBG11327
orthologous to F20D6.11 by best mutual match (eval=0)
cb25.fpc2454: 865621-867902
Taxon: Caenorhabditis briggsae [6238]
CBG13330
orthologous to Y56A3A.32 by best mutual match (eval=0)
cb25.fpc2976: 656179-658795
Taxon: Caenorhabditis briggsae [6238]
cr01.sctg35.wum.37
Contig35.Fgenesh_Celegans.1.final
Contig35: 168920-171869
Taxon: Caenorhabditis remanei [31234]
dana_GLEANR_15367_caf1
scaffold_12916: 6317619-6320327
Taxon: Drosophila ananassae [7217]
dere_GLEANR_6449_caf1
scaffold_4845: 5192195-5193820
Taxon: Drosophila erecta [7220]
dere_GLEANR_9522_caf1
scaffold_4929: 2186540-2189462
Taxon: Drosophila erecta [7220]
dgri_GLEANR_10227_caf1
scaffold_15252: 11689490-11692234
Taxon: Drosophila grimshawi [7222]
dmoj_GLEANR_1645_caf1
scaffold_6500: 1108606-1111289
Taxon: Drosophila mojavensis [7230]
dper_GLEANR_20844_caf1
scaffold_1: 5765729-5768489
Taxon: Drosophila persimilis [7234]
dsec_GLEANR_18398_caf1
scaffold_7: 2707097-2708716
Taxon: Drosophila sechellia [7238]
dsec_GLEANR_676_caf1
scaffold_121: 20345-23237
Taxon: Drosophila sechellia [7238]
dsim_GLEANR_5545_caf1
2L: 18771330-18772949
Taxon: Drosophila simulans [7240]
dsim_GLEANR_6874_caf1
2L: 2105796-2108688
Taxon: Drosophila simulans [7240]
dvir_GLEANR_1015_caf1
scaffold_12963: 8497037-8499719
Taxon: Drosophila virilis [7244]
dwil_GLEANR_15414_caf1
scf2_1100000004521: 2154058-2157556
Taxon: Drosophila willistoni [7260]
dyak_GLEANR_12907_caf1
2R: 5592979-5594610
Taxon: Drosophila yakuba [7245]
dyak_GLEANR_1925_caf1
2L: 2123551-2126551
Taxon: Drosophila yakuba [7245]
ENSBTAG00000006838
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 6729476-6759878
Taxon: Bos taurus [9913]
ENSBTAG00000038132
hypothetical protein LOC526295 [Source:RefSeq_peptide;Acc:NP_001039746]
chromosome17: 75675771-75680439
Taxon: Bos taurus [9913]
ENSCAFG00000018747
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 104337918-104370062
Taxon: Canis familiaris [9615]
ENSCING00000005922
chromosome2q: 3311554-3321100
Taxon: Ciona intestinalis [7719]
ENSCING00000007693
chromosome12q: 1070876-1074979
Taxon: Ciona intestinalis [7719]
ENSCPOG00000003140
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_1130: 174405-181690
Taxon: Cavia porcellus [10141]
ENSCPOG00000013569
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_4805: 112375-179173
Taxon: Cavia porcellus [10141]
ENSCSAVG00000000045
reftigreftig_613: 36964-39259
Taxon: Ciona savignyi [51511]
ENSCSAVG00000005720
reftigreftig_431: 572485-579549
Taxon: Ciona savignyi [51511]
ENSCSAVG00000008193
reftigreftig_54: 1256607-1261687
Taxon: Ciona savignyi [51511]
ENSDARG00000058088
programmed cell death 8 (apoptosis-inducing factor) [Source:RefSeq_peptide;Acc:NP_956396]
chromosome5: 12211788-12234244
Taxon: Danio rerio [7955]
ENSDARG00000061634
hypothetical protein LOC791218 [Source:RefSeq_peptide;Acc:NP_001074169]
chromosome18: 44157061-44165228
Taxon: Danio rerio [7955]
ENSDARG00000062780
chromosome5: 5369056-5406300
Taxon: Danio rerio [7955]
ENSDNOG00000011568
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_1123: 97660-106687
Taxon: Dasypus novemcinctus [9361]
ENSDNOG00000018718
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_4820: 14991-60632
Taxon: Dasypus novemcinctus [9361]
ENSECAG00000001360
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 103402028-103432267
Taxon: Equus caballus [9796]
ENSEEUG00000011290
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_7802: 32757-79683
Taxon: Erinaceus europaeus [9365]
ENSEEUG00000015010
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_5570: 2063-48670
Taxon: Erinaceus europaeus [9365]
ENSETEG00000003183
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_1489: 63682-88923
Taxon: Echinops telfairi [9371]
ENSFCAG00000006006
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_2882: 714615-722092
Taxon: Felis catus [9685]
ENSFCAG00000008451
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_565: 221282-243741
Taxon: Felis catus [9685]
ENSGACG00000008468
groupgroupI: 7524700-7529201
Taxon: Gasterosteus aculeatus [69293]
ENSGACG00000009355
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
groupgroupXIII: 9276082-9283757
Taxon: Gasterosteus aculeatus [69293]
ENSGACG00000020327
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
groupgroupVII: 17045969-17058141
Taxon: Gasterosteus aculeatus [69293]
ENSGACG00000020479
groupgroupVII: 19122393-19127881
Taxon: Gasterosteus aculeatus [69293]
ENSGALG00000004003
programmed cell death 8 [Source:RefSeq_peptide;Acc:NP_001007491]
chromosome4: 1566014-1578202
Taxon: Gallus gallus [9031]
ENSGALG00000007720
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome15: 10316849-10331786
Taxon: Gallus gallus [9031]
ENSGALG00000023787
chromosome19: 5344145-5349631
Taxon: Gallus gallus [9031]
ENSLAFG00000008118
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_6586: 10959-49666
Taxon: Loxodonta africana [9785]
ENSLAFG00000008831
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_3187: 20502-49791
Taxon: Loxodonta africana [9785]
ENSMICG00000014580
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_4051: 15630-26736
Taxon: Microcebus murinus [30608]
ENSMICG00000016006
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_552: 200102-234915
Taxon: Microcebus murinus [30608]
ENSMLUG00000008966
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_703: 164693-212713
Taxon: Myotis lucifugus [59463]
ENSMLUG00000014962
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_871: 41178-53980
Taxon: Myotis lucifugus [59463]
ENSMMUG00000004954
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 128363842-128400386
Taxon: Macaca mulatta [9544]
ENSMMUG00000020478
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome10: 64922254-64936018
Taxon: Macaca mulatta [9544]
ENSMODG00000013265
NULL
chromosomeX: 31601939-31628196
Taxon: Monodelphis domestica [13616]
ENSMUSG00000036932
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:Q9Z0X1]
chromosomeX: 45828293-45866515
Taxon: Mus musculus [10090]
ENSMUSG00000022763
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q3TY86]
chromosome16: 17492165-17507259
Taxon: Mus musculus [10090]
ENSOCUG00000002920
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_781: 230517-266289
Taxon: Oryctolagus cuniculus [9986]
ENSOCUG00000016484
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_6057: 3805-7525
Taxon: Oryctolagus cuniculus [9986]
ENSOGAG00000012692
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_3307: 114581-173811
Taxon: Otolemur garnettii [30611]
ENSOGAG00000013007
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_759: 265373-272428
Taxon: Otolemur garnettii [30611]
ENSOPRG00000003151
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_3196: 4720-31954
Taxon: Ochotona princeps [9978]
ENSOPRG00000008202
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_4574: 17104-27097
Taxon: Ochotona princeps [9978]
ENSORLG00000002601
chromosome14: 8573638-8580572
Taxon: Oryzias latipes [8090]
ENSORLG00000007952
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome9: 13010356-13020018
Taxon: Oryzias latipes [8090]
ENSORLG00000007999
chromosome13: 16364411-16370092
Taxon: Oryzias latipes [8090]
ENSORLG00000009626
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosome14: 17407427-17421045
Taxon: Oryzias latipes [8090]
ENSPPYG00000012030
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome22_random: 2667182-2681302
Taxon: Pongo pygmaeus [9600]
ENSPPYG00000020712
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 129544973-129581418
Taxon: Pongo pygmaeus [9600]
ENSPTRG00000014095
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome22: 19705772-19719289
Taxon: Pan troglodytes [9598]
ENSPTRG00000022265
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 129569092-129606716
Taxon: Pan troglodytes [9598]
ENSRNOG00000006067
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:Q9JM53]
chromosomeX: 134869053-134908092
Taxon: Rattus norvegicus [10116]
ENSRNOG00000037957
RGD1306028 protein. [Source:Uniprot/SPTREMBL;Acc:Q5FVJ2]
chromosome11: 85496628-85510386
Taxon: Rattus norvegicus [10116]
ENSSARG00000003577
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_4531: 9131-82965
Taxon: Sorex araneus [42254]
ENSSTOG00000008362
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_1964: 391785-424424
Taxon: Spermophilus tridecemlineatus [43179]
ENSSTOG00000008699
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
genescaffoldGeneScaffold_6131: 35601-41202
Taxon: Spermophilus tridecemlineatus [43179]
ENSG00000156709
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosomeX: 129091212-129127311
Taxon: Homo sapiens [9606]
ENSG00000183773
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome22: 19652232-19665320
Taxon: Homo sapiens [9606]
ENSTBEG00000017750
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
genescaffoldGeneScaffold_617: 122994-174747
Taxon: Tupaia belangeri [37347]
ENSTNIG00000011831
Apoptosis-inducing factor 1, mitochondrial precursor (EC 1.-.-.-) (Programmed cell death protein 8). [Source:Uniprot/SWISSPROT;Acc:O95831]
chromosome7: 6504161-6510080
Taxon: Tetraodon nigroviridis [99883]
ENSTNIG00000015901
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
chromosome12: 6142536-6146262
Taxon: Tetraodon nigroviridis [99883]
ENSTNIG00000016126
chromosome7: 8316695-8320284
Taxon: Tetraodon nigroviridis [99883]
ENSTNIG00000017963
chromosome10: 10583083-10589272
Taxon: Tetraodon nigroviridis [99883]
ENSXETG00000018186
scaffoldscaffold_615: 532448-547823
Taxon: Xenopus tropicalis [8364]
ENSXETG00000008277
Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor- like protein). [Source:Uniprot/SWISSPROT;Acc:Q96NN9]
scaffoldscaffold_7: 673179-704689
Taxon: Xenopus tropicalis [8364]
F20D6.11
F20D6.11 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to human AIFM3 (AIFL), and paralogous to WAH-1 and mammalian PDCD8 (AIF. OMIM:300169, mutated in Harlequin mice). F20D6.11 is expressed in pharynx, anal depressor and body wall muscles, the reproductive system (including spermatheca), and unidentified tail cells. given its orthology to AIFM3, F20D6.11 may promote apoptosis. however, F20D6.11 has no obvious function in mass RNAi assays. [Source: WormBase]
chromosomeV: 8196931-8199064
Taxon: Caenorhabditis elegans [6239]
FBgn0025628
chromosomeX: 1960741-1967211
Taxon: Drosophila melanogaster [7227]
FBgn0031392
chromosome2L: 2152034-2154897
Taxon: Drosophila melanogaster [7227]
FBgn0032754
chromosome2L: 19077375-19078995
Taxon: Drosophila melanogaster [7227]
Smp_137540
disulfide oxidoreductase, putative
Smp_scaff000059: 729127-743977
Taxon: Schistosoma mansoni [6183]
SPAC26F1.14c
apoptosis-inducing factor homolog Aif1
chromosome1: 5146272-5148000
Taxon: Schizosaccharomyces pombe [4896]
Y56A3A.32
wah-1 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to mammalian PDCD8 (AIF. OMIM:300169, mutated in Harlequin mice). WAH-1 is required for apoptotic DNA degratation, SCRM-1 phospholipid scramblase activity, phosphatidylserine exposure, rapid apoptosis during embryonic development, and rapid engulfment of apoptotic cells in the germline. WAH-1 is also required for normally rapid growth and large brood sizes, and has a subtle proapoptotic function revealed in ced-3 or ced-4 mutant backgrounds. WAH-1 is expressed in most, if not all, cells of embryos and larvae. WAH-1 is normally mitochondrial, but can be released into the cytosol and nucleus by EGL-1 and CED-3. residues 380-550 of WAH-1 specifically bind SCRM-1 in vitro, but not SCRM-2 through SCRM-4, and WAH-1 binding is required in liposomes for more than residual SCRM-1 activity. WAH-1 also binds and activates CPS-6, promoting apoptotic DNA degradation, and transgenic coexpression of WAH-1 with CPS-6 specifically induces ectopic CED-3-dependent apoptosis in touch receptor neurons. CPS-6 shares a genetic pathway with WAH-1, whereas CED-3, CED-4, CED-8, and NUC-1 act independently of it. WAH-1 is paralogous to C. elegans F20D6.11 and human AIFM3 (AIFL). [Source: WormBase]
chromosomeIII: 11990080-11999333
Taxon: Caenorhabditis elegans [6239]
Last Modified Thu Aug 2 03:14:18 2007 treefam@sanger.ac.uk